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EpiCor® Postbiotic

For professional audience only.

Differentiate with EpiCor® Postbiotic 

  • Clinically Researched. Over a dozen published studies, including multiple clinical human trials, show that it helps support the immune system, nasal comfort and positively modulate the gut microbiome. 
  • #1 Postbiotic Brand1. Postbiotics is an emerging, new health ingredient that consumers are excited about and with our investment in consumer marketing and supporting our customers products, EpiCor® is the leading postbiotic brand.
  • Easy to Formulate. EpiCor® postbiotic is PH and heat stable making it suitable for many applications. 
  • Label-Friendly. Made in the USA, EpiCor® postbiotic is label-friendly with certifications and designations such as Non-GMO Project Verified, FDA GRAS no objection, vegan/vegetarian, gluten free, kosher, halal and BSE/TSE free.

1. According to Innova Data (July 2021).

EpiCor Applications


Epicor logo What is EpiCor®? 

EpiCor® postbiotic is a dried yeast fermentate derived from the proprietary fermentation of Saccharomyces cerevisiae, or baker’s yeast. The end result is a nutritious whole food with a unique fingerprint of metabolites including proteins, vitamins, minerals, antioxidants and polyphenols, fibers and polysaccharides (beta-1.3/1.6-glucans, mannans), and other nutrients. Adhering to the newly released consensus definition of a postbiotic, EpiCor is a preparation of inanimate microorganisms and components that may support immune and gut health functions as substantiated in over a dozen published studies. 


What are Postbiotics?

The ISAPP consensus definition and scope for probiotics is: “A preparation of inanimate microorganisms and/or their components that confers a health benefit on the host”. EpiCor is a preparation of inanimate microorganisms and components that may support immune and gut health functions as substantiated in over a dozen published studies. Contrary to probiotics which needs to be kept alive in the digestive tract to deliver an effect, EpiCor® postbiotic is intentionally heat-killed or inanimate, with proven efficacy. This inanimate makeup offers multiple advantages by minimizing stability issues in Food & Beverage formulation and processing. Compared to prebiotics, it allows for lower efficacious dose of only 500mg (for adults).


Postbiotics vs. Pre- & Probiotics

Learn about a new health category that is revolutionizing the immune and gut health space.

Next Evolution in Immune and Gut Health: Postbiotics

Learn about how Cargill's Health Technology business is a leader in postbiotic technology.

What's the Difference? Prebiotics, Probiotics & Postbiotics

This infographic helps easily explain what makes postbiotics unique.

How It's Made

The process of fermentation - EpiCor Postbiotic Made in in the USA, EpiCor® postbiotic is made in a state-of-the-art facility that follows all current Good Manufacturing Processes (cGMP) certified by NSF.  It is made through a specialized fermentation process that creates a unique fingerprint of metabolites and functional compounds consisting of proteins, peptides, antioxidants, polyphenols, organic acids, nucleotides, polysaccharides (1-3 1-6, beta glucans, and mannans).

To make EpiCor®, we start with baker’s yeast, Saccharomyces cerevisiae, and feed it a proprietary broth of natural, plant-based ingredients. It then goes through a specialized fermentation process where the yeast is deprived of oxygen, which causes them to produce beneficial metabolites. 

The final production step uses a proprietary and gentle drying process that deactivates the yeast (there are NO live yeast or other organisms in EpiCor® postbiotic) and preserves the complex array of metabolites created during fermentation. EpiCor® postbiotic is considered a “whole food” fermentate because nothing is extracted or purified - we use the whole fermentation broth and gently dry it to a powder. The dehydrated whole food fermentate is then milled to a fine powder and packaged within containers designed to protect it during storage and handling. 

Following extensive safety and identity testing, the result is EpiCor® postbiotic – a whole food yeast fermentate that helps support the immune system and positively modulate the gut microbiome.

How it Works

Over a dozen published studies show that EpiCor® has a wide range of real-life health benefits. These studies show EpiCor® supports a strong immune system and healthy gut to help people live more healthy days™. EpiCor® postbiotic:

Maintains daily immune health

Supports year-round nasal comfort

Positively modulates the gut microbiome

Supports digestive health

Made through a natural fermentation process, EpiCor® postbiotic supports a healthy gut microbiome which, as ongoing research suggests, helps to support a healthy immune system. It is rich with metabolites and when taken daily acts like a vitamin for your immune system™.


Versatility is one of the key advantages of postbiotics; they offer increased stability and consistency as compared to the more familiar ingredients like probiotics. Probiotics are inherently harder to work with than metabolites in postbiotics because they must remain alive – from processing and packaging until they reach the consumer’s gut. 

EpiCor® postbiotic is well-suited to a wide range of food and beverage applications. It is not a living organism and is highly heat stable. In addition, EpiCor® postbiotic can handle varying pH levels and has a three-year shelf life from its manufacture date. 

EpiCor - Applications of use

EpiCor Research:

Human Clinical Trials: Winter Immune Support

1. Moyad, M. A.,  et al. Effects of a modified yeast supplement on cold/flu symptoms. Urol Nurs 2008, 28 (1), 50-5.

Read the abstract

2. Moyad, M. A., et all.  Immunogenic yeast-based fermentate for cold/flu-like symptoms in nonvaccinated individuals. J Altern Complement Med 2010, 16 (2), 213-8.  

Read the abstract



EpiCor Postbiotic Research Study - EpiCor Impacts Cold and Flu Symptoms on Healthy Adults

Download Report




The information shared is designed to provide professionals within the food industry with an overview of the immunity and gut health attributes of Cargill's EpiCor® Dried yeast fermentate produced by Saccharomyces cerevisiae and provide the current state of the research and studies which back this up.  

The contents are NOT intended to serve as the basis for any claims that professionals within the food industry may choose to consider on consumer food products for European jurisdictions, noting that currently no health claims for this product have been submitted nor approved under the EU Health & Nutrition Claims Regulation N° 1924/2006 and any claim that a product is intended for the prevention, curing or treatment of disease in humans would qualify the product as a medicine. 

The information presented herein is believed to be true and accurate. However, all statements are made and all information is provided without guarantee, express or implied, on our part. WE DISCLAIM ALL WARRANTIES, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE IMPLIED WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE and FREEDOM FROM INFRINGEMENT and disclaim all liability in connection with the use of the products or information contained herein. All such risks are assumed by the purchaser/user. The information contained herein is subject to change without notice. This information is offered solely for your consideration, investigation and verification.

Copyright Notice: © Cargill, Incorporated 2022


Some Cargill products are only approved for use in certain geographies, end uses, and/or at certain usage levels. It is the customer's responsibility to determine, for a particular geography, that (i) the Cargill product, its use and usage levels, (ii) the customer's product and its use, and (iii) any claims made about the customer's product, all comply with applicable laws and regulations.