Direct compression

Direct compression has become the pharmaceutical industry's preferred tabletting process, due to its simplicity and the fact that ingredients are not exposed to heat and moisture. But the choice of the right excipient is critical: it must combine high compressibility with excellent flowability, and have a particle size distribution compatible with the active ingredient.

Each of our direct compression products feature a specific set of characteristics that meet a particular application requirement.

Product	Function	Brandname
Pregelatinized starch	Binder	CPharmGel™
Maltodextrin	Diluent-binder	CPharmDry™
Sorbitol	Diluent-binder	CPharmSorbidex™ P

Dry granulation

Dry granulation is gaining popularity as a preparation technique for the manufacture of compressed tablets especially for ingredients sensitive to solvents and labile at high temperatures. An advantage of this technique as well is that high density granules can be obtained.

Several of Cargill's sweet excipients can be used in this technique, providing excellent tablets without any sign of capping or laminating.

Product	Function	Brandname
Monohydrous dextrose	Diluent-binder	CPharmDex™
Sorbitol	Binder	CPharmSorbidex™ P
Mannitol	Diluent	CPharmMannidex™

Wet granulation

Granulation remains an essential and sometimes inevitable process in the development of solid-dosage forms. We offer a wide range of excipients suitable for wet granulation, including starches, maltodextrins and polyols.

Each product has been developed to demonstrate a unique set of functionalities in a particular application. Our long-lasting relationships with customers often extend to the development of solutions and formulations that meet their unique requirements.

All of our products meet the appropriate Ph. Eur, USP/NF and JP(E) specifications, and all are manufactured in line with appropriate quality management systems.

Starch is widely used as an excipient in wet granulation that, depending on its structure, can be used as a binder, diluent or disintegrant. We offer pregelatinized and partly pregelatinized starches, as well as native starches. Dextrose and polyols have also been developed as binders or diluents.

Product	Function	Brandname
Pregelatinized starch	Binder	CPharmGel™
Maltodextrin	Binder	CPharmDry™
Isomalt	Binder	CPharmIsoMaltidex™
Sorbitol syrup "non-crystalizing"	Binder	CPharmSorbidex™ NC
Monohydrous dextrose	Diluent	CPharmDex™
Sorbitol	Diluent	CPharmSorbidex™ S
Sorbitol	Diluent	CPharmSorbidex™ P
Mannitol	Diluent	CPharmMannidex™
Erythritol	Diluent	Zerose™
Native maize starch	Diluent	CPharmGel™