EpiCor® Postbiotic

Postbiotics for immune support & gut health

EpiCor® is a science-backed postbiotic ingredient—the result of a real-life health discovery, advanced through intentional innovation.

More and more, the positive effects the gut microbiome can have on health, brain, digestive and immune systems are becoming evident. As a highly stable ingredient, EpiCor® can be easily formulated into dietary supplements, foods, beverages, and even pet-health applications.

Why choose EpiCor® postbiotic:

#1 postbiotic ingredient — EpiCor® is formulated into more products than any other postbiotic.*

Supported by research — In 15+ published studies, EpiCor® is clinically shown to support immune health and positively modulate the gut microbiome.

80+ years of fermentation expertise with a proven history of experience and reliability.

The ISAPP consensus definition and scope for postbiotics, which EpiCor adheres to fully, is: “A preparation of inanimate microorganisms and/or their components that confers a health benefit on the host”.

The next evolution in immune and gut health

As a leader in understanding the microbiome, Cargill’s mission is to help people and animals live more healthy days.™ Learn more about the postbiotic clinically shown to support immune health.

View EpiCor® brochure

View EpiCor® sellsheet

Postbiotic Research

New study finds the body responds to EpiCor® postbiotic within hours*

Published clinical research shows that after a single serving (500 mg), the body exhibits measurable changes in immune-related markers.

View research summary (PDF)

*Published in Frontiers in Nutrition, August 6, 2026. Funded by Cargill and conducted by an independent lab.

Fast-acting: effects within 3 hours
Coordinated immune-related biomarker shifts vs. placebo

From discovery to innovation

EpiCor’s serendipitous origins have resulted in 80+ years of fermentation expertise. Our journey is a testament of turning observation into a time-tested commitment to excellence.

Epic origin story

How a serendipitous discovery in 1998 started it all.

The power of fermentation

How EpiCor® consistently delivers a complete postbiotic.

Formulation & Application

Experience versatility and simplicity with EpiCor® postbiotics

Supplements

Food & beverage

Pet health

As a highly stable ingredient, EpiCor® can be easily formulated into dietary supplements, functional food and beverage offerings, or even Pet Food, Treats, and Supplements.

A whole-food fermentate ingredient
EpiCor® features a unique fingerprint of metabolites, including proteins, peptides, antioxidants, polyphenols, organic acids, nucleotides, polysaccharides (beta-1,3/1,6-glucans) and mannans.

Stable and consistent
Experience simplicity without compromising efficacy. As an inanimate ingredient, EpiCor® offers increased stability and consistency as compared to more familiar immune ingredients such as probiotics.

Low-dose benefits
In clinical studies EpiCor® probiotic is shown to be effective at a daily dose of only 500mg.

Extensive shelf-life
Enjoy longevity without compromise. EpiCor® offers a three-year shelf life from date of manufacture.

Learn more about the postbiotic clinically shown to support immune health.

View EpiCor® brochure View EpiCor® sellsheet

EpiCor® formulation certifications

Made in the USA, EpiCor® has earned certifications and designations including:

Non-GMO*
NSP Certified
FDA GRAS No Objection
Certified Halal
Certified OU Kosher
Vegan/vegetarian
Gluten free
TSE/BSE free

*Non-GMO Project Verified. There is no single definition of “non-GMO” in the USA. Contact Cargill for source and processing information.

Gummy Innovation

Creating gummies infused with EpiCor® postbiotic? We can support you at every stage.

Cargill has teamed up with a leading producer to help you develop EpiCor®‑infused gummies with expert formulation, precise texture, and seamless flavor integration. Together, we turn functional concepts into scalable, high‑quality products. With turnkey support from concept through final production, you get a true one‑stop shop for custom gummy innovation.

Contact us

EpiCor® postbiotic research

Numerous published studies have clinically shown EpiCor® supports immune and gut health

Immune support studies

Human clinical trial

A yeast-derived postbiotic fermentate rapidly modulates inflammatory cytokines and immune surveillance markers in healthy adults: a randomized double-blind placebo-controlled cross-over trial.

Jensen, G. S., et al. / Front Nutr. 2026;13:1897550.

Download summary (PDF)

Human clinical trial

Anti-inflammatory properties of a dried fermentate in vitro and in vivo.

Jensen GS, et al. / J Med Food. 2014;18(3):378-384.

Read the abstract

Human clinical trial

Immunogenic yeast-based fermentate for cold/flu-like symptoms in nonvaccinated individuals.

Moyad MA, et al. / J Altern Complement Med. 2010;16(2):213-218.

Read the abstract

Human clinical trial

Antioxidant bioavailability and rapid immune-modulating effects after consumption of a single acute dose of a high-metabolite yeast immunogen: results of a placebo-controlled double-blinded crossover pilot study.

Jensen GS, et al. / J Med Food. 2010;14:1002-1010.

Read the abstract

Human clinical trial

Immunogenic yeast-based fermentation product reduces allergic rhinitis-induced nasal congestion: a randomized, double-blind, placebo-controlled trial.

Moyad MA, et al. / Adv Ther. 2009;26(8):795-804.

Read the abstract

Human clinical trial

Effects of a modified yeast supplement on cold/flu symptoms.

Moyad MA, et al. / Urol Nurs. 2008;28(1):50-55.

Read the abstract

Human clinical trial

A double-blind placebo-controlled, randomized pilot study: consumption of a high-metabolite immunogen from yeast culture has beneficial effects on erythrocyte health and mucosal immune protection in healthy subjects.

Jensen GS, et al. / Open Nutr J. 2008;2:68-75.

Read the abstract

Preclinical trial

An anti-inflammatory immunogen from yeast culture induces activation and alters chemokine receptor expression on human natural killer cells and B lymphocytes in vitro.

Jensen GS, et al. / Nutr Res. 2007;27:327-335.

Read the abstract

Gut health support studies

Human clinical trial

A yeast fermentate improves gastrointestinal discomfort and constipation by modulation of the gut microbiome: results from a randomized double-blind placebo-controlled pilot trial.

Pinheiro I, et al. / BMC Complement Altern Med. 2017;17(1):441.

Read the abstract

Preclinical trial

Yeast fermentate prebiotic improves intestinal barrier integrity during heat stress by modulation of the gut microbiota in rats.

Ducray HAG, et al. / J Appl Microbiol. 2019;127:1192-1206.

Read the abstract

Online reference

Preclinical trial

Mitigation of heat stress-related complications by a yeast fermentate product.

Ducray HAG, et al. / J Therm Biol. 2016;60:26-32.

Read the abstract

Online reference

Preclinical trial

The HMI module: a new tool to study the Host-Microbiota Interaction in the human gastrointestinal tract in vitro.

Marzorati M, et al. / BMC Microbiol. 2014;14(1):133.

Read the abstract

Preclinical trial

A dried yeast fermentate selectively modulates both the luminal and mucosal gut microbiota and protects against inflammation, as studied in an integrated in vitro approach.

Possemiers S, et al. / J Agric Food Chem. 2013;61(39):9380-9392.

Read the abstract

Partner with Cargill

Meet the rising demand for gut & immune health

From concept to commercialization, Cargill’s team brings the science, stability and formulation expertise
to help you build with EpiCor® postbiotic.

Postbiotics for immune support & gut health

Why choose EpiCor® postbiotic:

New study finds the body responds to EpiCor® postbiotic within hours*

From discovery to innovation

Epic origin story

The power of fermentation

Formulation & Application

Supplements

Food & beverage

Pet health

EpiCor® formulation certifications

Creating gummies infused with EpiCor® postbiotic? We can support you at every stage.

EpiCor® postbiotic research

A yeast-derived postbiotic fermentate rapidly modulates inflammatory cytokines and immune surveillance markers in healthy adults: a randomized double-blind placebo-controlled cross-over trial.

Anti-inflammatory properties of a dried fermentate in vitro and in vivo.

Immunogenic yeast-based fermentate for cold/flu-like symptoms in nonvaccinated individuals.

Antioxidant bioavailability and rapid immune-modulating effects after consumption of a single acute dose of a high-metabolite yeast immunogen: results of a placebo-controlled double-blinded crossover pilot study.

Immunogenic yeast-based fermentation product reduces allergic rhinitis-induced nasal congestion: a randomized, double-blind, placebo-controlled trial.

Effects of a modified yeast supplement on cold/flu symptoms.

A double-blind placebo-controlled, randomized pilot study: consumption of a high-metabolite immunogen from yeast culture has beneficial effects on erythrocyte health and mucosal immune protection in healthy subjects.

An anti-inflammatory immunogen from yeast culture induces activation and alters chemokine receptor expression on human natural killer cells and B lymphocytes in vitro.

A yeast fermentate improves gastrointestinal discomfort and constipation by modulation of the gut microbiome: results from a randomized double-blind placebo-controlled pilot trial.

Yeast fermentate prebiotic improves intestinal barrier integrity during heat stress by modulation of the gut microbiota in rats.

Mitigation of heat stress-related complications by a yeast fermentate product.

The HMI module: a new tool to study the Host-Microbiota Interaction in the human gastrointestinal tract in vitro.

A dried yeast fermentate selectively modulates both the luminal and mucosal gut microbiota and protects against inflammation, as studied in an integrated in vitro approach.

Meet the rising demand for gut & immune health

Food & beverage